Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas.
نویسندگان
چکیده
AIM To evaluate the diagnostic value of telomerase expression in intracranial tumours. METHODS 98 surgical specimens from different neoplasms were analysed by the telomeric repeat amplification protocol (TRAP) and the presence of telomerase compared with the histological diagnosis and the proliferation index. RESULTS A high degree of positivity for telomerase activity was found in glioblastomas and atypical/anaplastic meningiomas. Telomerase activity was poorly detected in anaplastic astrocytomas. CONCLUSIONS The TRAP assay seems to be a valuable index for identifying meningeal tumours with aggressive behaviour.
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عنوان ژورنال:
- Journal of clinical pathology
دوره 52 3 شماره
صفحات -
تاریخ انتشار 1999